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ng1957 Figure 5C
 

The research in our lab is directed towards answering two questions:

  1. How do cells and organisms process signals from their environment?
  2. How do the underlying molecular pathways evolve?

To answer these questions we use a combination of computational, theoretical and experimental tools. Our experimental work has focussed on specific pathways in the yeast Saccharomyces cerevisae.


 
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Publications:
  1. Mody A., Weiner J., Ramanathan S., (2009) Modularity of MAP kinases allows deformation of their signaling pathways. Nature Cell Biology11, 484 - 491
  2. McClean M.N., Hersen P., Ramanathan S., (2009) In vivo measurement of signaling cascade dynamics. Cell Cycle 8 373-376.
  3. Hersen P., McClean M.N., Mahadevan L., Ramanathan S., (2008) Signal Processing by the HOG MAP kinase pathway. Proc. Natl. Acad. Sci. USA 105 (20) 7165-7170 [PDF][Materials for microfluidics][Mask for lithography][Compiled Visual Basic code to run switches]
  4. Nachman I., Ramanathan S., (2008) HIV-1 positive feedback and lytic fate. Nature Genetics 40 (4), 382-383. (N&V)
  5. Hallatschek O., Hersen, P., Ramanathan, S., and Nelson, D. (2007) Genetic drift at expanding frontiers promotes gene segregation. Proc. Natl. Acad. Sci. USA 104 (50), 19926-30 [PDF]
  6. Nachman, I., Regev, A., and Ramanathan, S. (2007) Dissecting Timing Variability in Yeast Meiosis. Cell 131, 544-556.
  7. Ramanathan, S., and Broach, J. (2007). Do cells think? Cell. Mol. Life Sci. 64, 1801-4 .
  8. McClean, M. N., Mody, A., Broach, J., and Ramanathan, S. (2007). Decision Making in MAP Kinase pathways. Nat. Genet. 39, 409-414. [PDF]
  9. Ramanathan, S., and Swain, P. (2005). Tracing the Sources of Cellular Variation. Dev. Cell 9, 576-578. (N&V)
  10. Ramanathan, S., Detwiler, P. B., Sengupta, A. M. and Shraiman, B. I. (2005). G-protein-coupled enzyme cascades have intrinsic properties that improve signal localization and fidelity”. Biophy. J. 88, 3063-3071. [PDF]
  11. Basu. A., Boshes, B., Mukherjee, S., and Ramanathan, S. (2004). Network Deformation: traffic-aware algorithms for dynamically reducing end-to-end delay in multi-hop wireless networks. Proc. IEEE ACM MobiCom 100-113. [PDF]
  12. Basu, A., Dutta, D., and Ramanathan, S. (2004). Characteristic Timescales: Analyzing end-to-end delay in networks under high loads, Bell Laboratories Technical Memorandum, ITD-03-44953M. [PDF]
  13. Basu, A., Lin, A., and Ramanathan, S. (2003). Routing using potentials: Dynamic Traffic Aware Routing Algorithms. Proc. IEEE ACM SigComm 37-48 (2003). [PDF]
  14. D’Souza, R., Temple Lang, D., and Ramanathan, S. (2003). Measuring performance of ad hoc networks using timescales for information flow. Proc. IEEE Infocom. [PDF]
  15. Mach, P., Kerbage, C., Ramanathan, S., Windler, R., Eggleton, B., and Rogers, J. (2002) Influence of Scattering on Transmission through Long-period Fiber Gratings and Tunable Microstructure Fibers. Applied Optics 33, 7018-7024.
  16. Bouchaud, E., Bouchaud, J. P., Fisher, D. S., Ramanathan, S., and Rice, J. R.,  (2002).Can crack front waves explain the roughness of cracks. J. Mech. Phys. Solids 50, 1703. [PDF]
  17. Detwiler PB, Ramanathan S, Sengupta A, Shraiman BI., Engineering aspects of enzymatic signal transduction: photoreceptors in the retina, Biophys J., 79(6):2801-17 (2000).
  18. Ramanathan, S., Fisher D.S., Onset of crack propagation in heterogeneous media, Phys. Rev. B., 58, 6026 - 6046 (1998)
  19. Fisher, DS, Dahmen, K., Ramanathan, S., Ben-Zion, Y., Statistics of Earthquakes in simple models of heterogeneous faults, Phys. Rev. Lett., 78, 4885-4888 (1997).
  20. Ramanathan, S., Ertas, D. and Fisher, D. S., Quasistatic crack propagation in heterogeneous media, Phys. Rev. Lett., 79, 873 (1997).
  21. Ramanathan, S., and Fisher, D. S., Dynamics and instabilities of planar tensile cracks in heterogeneous media, Phys. Rev. Lett., 79, 877, (1997).
  22. Ramanathan, S., Shakhnovich, E. I., Statistical Mechanics of proteins with evolutionarily selected sequences, Phys. Rev. E., 50, 130 (1994).

 

Patents:
  1. United States Patent 6,408,118, A. Ahuja, J. Rogers, B. Eggleton, S. Ramanathan, S. H. Simon, Optical Waveguide Gratings having Roughened Cladding for Reduced Short Wavelength Cladding Mode Loss.
  2. United States Patent 6970714,, R. D’Souza, S. Ramanathan, D. Temple-Lang, Adaptive Power Level Setting in an Adhoc Wireless Network.
  3. United States Patent 7260064, A. Basu, A. Lin, S. Ramanathan, Potential Based Routing Algorithm for Wired Networks.
  4. Basu 8-1-5-4, filed through Bell Labs, Method and Apparatus for dynamic routing using queue lengths.

 
   
           
Website design by Joan L. Weiner, Ph.D.